Yes. Medicare Part B generally covers Spravato given at a certified clinic. Here’s what it covers, what you may pay, and how Medicare Advantage differs.
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Original Medicare covers Spravato (esketamine) under Part B when it’s given at a REMS-certified clinic for treatment-resistant depression or major depressive disorder with suicidal thoughts or actions. The visit, dose, and two-hour observation are billed together.
Under Original Medicare you typically pay 20% coinsurance after the Part B deductible. A Medigap (Medicare Supplement) plan may cover some or all of that. Medicare Advantage plans must cover it too, but often add prior authorization or step-therapy rules.
Based on CMS billing and coding guidance for esketamine. Medicare Advantage plans may add requirements.
Different criteria apply to depression with acute suicidal thoughts. If you are in crisis, call or text 988.
Original Medicare (with or without Medigap) or a Medicare Advantage plan. The rules differ.
Choose a certified Spravato clinic that accepts Medicare, or is in network with your Advantage plan.
A prescriber confirms Spravato is right for you and documents your history.
You can’t drive until the next day after a restful sleep, so arrange transportation for each visit.
The manufacturer’s Spravato withMe savings program can’t be used with Medicare.
Have a different plan? See Spravato coverage by insurer, or find a Spravato clinic near you.
Sources: CMS Medicare Coverage Database, Billing and Coding article A59249 (esketamine); Janssen Spravato payer coverage and reimbursement (spravatohcp.com), including HCPCS G2082/G2083; FDA Spravato prescribing information (2025).
Clear answers to the questions people ask before choosing a clinic.
Yes. Medicare Part B generally covers Spravato given at a REMS-certified clinic for its FDA-approved uses.
Under Original Medicare you typically pay 20% coinsurance after the Part B deductible. A Medigap plan may reduce or cover that. Medicare Advantage costs depend on your plan.
Medicare Advantage plans must cover what Original Medicare covers, but they often require prior authorization and proof that other antidepressants were tried first.
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