Usually, yes, for eligible adults with prior authorization. Here’s what UnitedHealthcare looks for and how to get started.
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UnitedHealthcare’s commercial medical benefit drug policy considers Spravato (esketamine) medically necessary for treatment-resistant depression and for major depressive disorder with acute suicidal thoughts or behavior, with prior authorization.
Approvals are granted for up to 12 months at a time. Because Spravato is given in the clinic, it’s typically billed under the medical benefit, so choosing an in-network clinic matters.
Summarized from UnitedHealthcare’s commercial Spravato policy. Your plan’s documents are the final word.
Different criteria apply to depression with acute suicidal thoughts. If you are in crisis, call or text 988.
Choose a certified Spravato clinic in network with your UHC plan.
List the antidepressants and treatments you’ve tried, with doses and dates.
The clinic submits prior authorization with your rating-scale scores.
To continue, UHC asks for recent scores showing a positive response. Approvals last up to 12 months.
Have a different plan? See Spravato coverage by insurer, or find a Spravato clinic near you.
Sources: UnitedHealthcare Commercial Medical Benefit Drug Policy, Ketamine and Esketamine (Spravato); UnitedHealthcare Spravato prior authorization notification (uhcprovider.com); FDA Spravato prescribing information (2025).
Clear answers to the questions people ask before choosing a clinic.
UnitedHealthcare commercial plans generally cover Spravato for eligible adults with prior authorization. Costs depend on your plan’s deductible, copay, or coinsurance.
Initial and renewal approvals are granted for no longer than 12 months. Renewal requires recent depression-scale scores showing a positive response.
Your clinic can usually appeal with additional records or a letter of medical necessity. A Same Team navigator can help you understand next steps.
Our navigation call is free for everyone. To see whether your plan covers Same Team’s separate coaching services, visit our accepted insurance page.
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